This guide covers toxic tort litigation from intake through resolution, organized around the causation problem that defines the field. Part one explains why these cases differ structurally from ordinary injury claims, and part two sets out the two-step causation framework and what each step requires. Part three covers exposure proof and dose reconstruction, the weakest link in most cases, and part four covers epidemiology, relative risk, and the criteria that make an association persuasive. Part five covers expert admissibility under Rule 702 and the Daubert trilogy, where most of these cases are actually decided. Part six covers latency, the discovery rule, and the statutes of repose that can end a meritorious case outright. Part seven covers defendants, theories, and the workers compensation bar, and part eight covers medical monitoring, fear of disease, and property damage claims. Part nine covers the environmental statutes and the public records they generate. Part ten covers aggregation, damages, and practice checklists for both sides.